# Larazotide

Tight-junction (zonulin) blocker trialled for celiac; very safe, but efficacy failed phase 3.

- Page: https://peprank.xyz/peptides/larazotide
- Category: Gut (Research peptide)
- Also known as: larazotide acetate; AT-1001; INN-202
- Routes: Oral
- Sequence: GGVLVQPG (none (AT-1001))
- Safety tier: Strict: Clean · Balanced: Clean · Evidence only: Clean
- Risk axes (0 none to 3 severe): Seen harm 0, Mechanism 0, Data gap 1, Silent harm 0, Product 2
- Positive: 56% of 6 graded reports glowing or positive, shrunk toward the 49% all-report average by 8 reports' weight
- Rank: #4 of 61 research peptides
- Graded reports: 6 (Glowing 1, Positive 3, Nothing 2)
- Evidence: Human RCTs — Phase 2b positive at 0.5 mg; phase 3 CedLara terminated for futility 2022; adverse events similar to placebo
- Access: Grey market
- Onset: within the meal, taken 15-20 minutes before eating
- Lasts: a few hours, so it is dosed before each meal
- Cost per month: ≈ €54–140 (researchers' estimate)
- Updated: 2026-10-30

## What users report

There are very few user reports (low confidence). A handful of celiac and long-COVID users take it before restaurant meals and feel less bloating. Most threads are people asking where to buy it, and GI doctors often haven't heard of it. There are no negative experience reports, but the base is too small to estimate a 'felt nothing' share.

**Effects:** less bloating after accidental gluten (anecdotal); gut-barrier support in long COVID / MIS-C (early research)

**Downsides:** hard to source; sold as a 'supplement' by a few vendors; efficacy uncertain

**Risks:** Generic: unregulated supplement-channel product of uncertain identity

**Typical use:** 0.5 mg orally ~15-20 min before meals (trial dose 0.5 mg three times daily).

**Getting it:** No approved product; a few online vendors sell it as a supplement or research peptide of unverified identity.

**Stacked with:** BPC-157 and KPV (the gut-repair stack long-COVID and leaky-gut users pair it with.); strict gluten-free diet (celiac users take it as insurance against cross-contamination, not as a licence to eat gluten.)

## Risk profile

- **Seen harm 0/3:** Adverse events matched placebo across RCTs with 465 people on drug, and the 307-patient phase 3 stopped for futility, not safety.
- **Mechanism 0/3:** A locally acting oral tight-junction regulator with minimal absorption; no pathway to serious harm is known.
- **Data gap 1/3:** RCTs with several hundred people up to 12 weeks, but never approved and phase 3 safety results were never published.
- **Silent harm 0/3:** No harm signal; GI effects, if any, would be immediate.
- **Product 2/3:** With no approved product, the few sources are online 'supplement' or research vendors whose identity and dose are unverified.
- **Never if:** Pregnancy or breastfeeding (no human reproductive data)

## Top reports

- Glowing, gut: “Helped tremendously with gastritis and GERD for me at least.” — [r/covidlonghaulers](https://www.reddit.com/r/covidlonghaulers/comments/1pcrarp/does_anyone_know_where_to_buy_larazotide/ojy52vl/)
- Positive, gut, Mass General MIS-C trial protocol: “Did it help? I'd say yes, a bit, but not as much as I'd hoped based on the impetus for the study.” — [r/covidlonghaulers](https://www.reddit.com/r/covidlonghaulers/comments/1pcrarp/does_anyone_know_where_to_buy_larazotide/ns3xp0g/)
- Positive, gut, taken 20 minutes before restaurant or takeout meals: “I take it 20 minutes before I eat meals at restaurants/take out! Also if I plan on eating something I know might cause a stomach ache, like pizza made from gluten-free wheat starch. If I take it early enough I definitely feel like it helps me be less bloated/not get a stomach ache” — [r/Celiac](https://www.reddit.com/r/Celiac/comments/1vcqdhj/has_anyone_tried_larazotide/p139l6i/)
- Positive, gut: “I also tried lorazotide and got benefit with this.” — [r/covidlonghaulers](https://www.reddit.com/r/covidlonghaulers/comments/1pcrarp/does_anyone_know_where_to_buy_larazotide/p5hi57v/)
- Nothing, gut: “My Zonulin was slightly elevated and taking Larazotide did nothing for me.” — [r/covidlonghaulers](https://www.reddit.com/r/covidlonghaulers/comments/1pcrarp/does_anyone_know_where_to_buy_larazotide/ns4nepj/)

## Cheapest in Europe

- [Condor Research](https://condorresearch.com/product/larazotide-capsules/) (SK): Larazotide Capsules 60 x 500mcg, €140, €4.66/mg

## Studies

- [Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/25683116/) (rct, n=342, 2015): 0.5 mg three times daily reduced symptoms versus placebo; the 1 mg and 2 mg doses did not.
- [Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23163616/) (rct, n=184, 2013): Reduced gluten-induced symptoms and antibody rise but did not change the gut-permeability marker.
- [Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide](https://pubmed.ncbi.nlm.nih.gov/40737433/) (rct, n=12, 2025): Children with MIS-C on larazotide cleared spike antigen and recovered faster than on placebo.

## Sources

- [Leffler et al., Larazotide acetate for persistent celiac symptoms: RCT (Gastroenterology 2015)](https://doi.org/10.1053/j.gastro.2015.02.008)
- [Phase 3 larazotide study discontinued (Beyond Celiac, 2022)](https://www.beyondceliac.org/research-news/phase-3-study-discontinued/)