# Pinealon

Khavinson tripeptide 'bioregulator'; sleep and circadian claims, mixed reports.

- Page: https://peprank.xyz/peptides/pinealon
- Category: Sleep (Research peptide)
- Also known as: EDR; Glu-Asp-Arg
- Routes: Oral / Injection
- Sequence: EDR (none)
- Safety tier: Strict: Caution · Balanced: Caution · Evidence only: Caution
- Risk axes (0 none to 3 severe): Seen harm 1, Mechanism 1, Data gap 2, Silent harm 1, Product 3
- Positive: 52% of 46 graded reports glowing or positive, shrunk toward the 49% all-report average by 8 reports' weight
- Rank: #9 of 61 research peptides
- Graded reports: 46 (Glowing 11, Positive 13, Mixed 4, Nothing 11, Negative 2, Bad reaction 5)
- Evidence: Small human studies — animal and in-vitro, plus small uncontrolled Russian human observations (single research group)
- Access: Grey market
- Onset: Some notice better sleep the first night; others only near the end of a 10-20 day course or 1-2 weeks after it.
- Lasts: Taken as 10-20 day courses two or three times a year; reported benefits last weeks to about two months, then fade.
- Cost per month: ≈ €27–81 (researchers' estimate)
- Dose users report: 1–2 mg/day (median 2 mg, n=9)
- Updated: 2026-10-30

## What users report

More favourable than its thin evidence suggests. Most first-hand reports describe better sleep (sleep score and HRV up, dreams returning) or a calmer, clearer head that outlasts a 10-20 day course by weeks, though many ran it with Epitalon. About a fifth felt nothing, including careful wearable trackers. Irritability and unrested sleep after 2 mg before bed, and oversleeping, show up; many advise morning dosing.

**Effects:** better sleep scores for some; vivid dreams; subtle daytime awareness/recall

**Downsides:** irritability when dosed at night; vivid dreams/unrested sleep; no effect for many; anhedonia (isolated report at 6 mg)

**Caveat:** Low confidence. Nearly all data come from the Khavinson group; one in-vitro paper describes 'activating proliferative processes' and the group claims gene-expression effects. That is weak and unreplicated, so not treated as a credible harm path, but it is the same family as Epitalon.

**Typical use:** 300 mcg-2 mg/day subq or oral for 10-20 days, mornings preferred.

**Getting it:** Research vials and nasal sprays; oral Russian bioregulator capsules are sold as supplements.

**Stacked with:** Epitalon (By far the most common pairing, often Pinealon in the morning and Epitalon at night; most of the strongest sleep reports used both.); DSIP (Tried together for sleep; some who did preferred Pinealon on its own.); Semax (Semax by day for focus and Pinealon in the evening; reported as clearer, calmer mornings.)

## Risk profile

- **Seen harm 1/3:** No study reports adverse events. One first-hand report of months of early waking and poor function followed an accidental overdose of Pinealon with Epitalon in someone with ME/CFS, so it is confounded; other reports are insomnia and next-day low mood.
- **Mechanism 1/3:** The originating group reports gene-expression effects and, in vitro, shifts in the cell cycle; its own 32-patient study saw a pro-oxidant signal and a fall in CD34+ blood stem cells it called inhibition of haemopoiesis. Single-group and unreplicated, so speculative.
- **Data gap 2/3:** Human data are small uncontrolled Russian studies (the largest 32 older patients, co-dosed with Vesugen) from the same research group, with no systematic safety reporting.
- **Silent harm 1/3:** Reported harms (insomnia, irritability, low mood) appear within a day of dosing.
- **Product 3/3:** Most reports describe injecting research vials, with nasal sprays and Russian oral capsules sold as supplements as the alternatives.
- **Never if:** Pregnancy or breastfeeding (no human reproductive data)

## Top reports

- Glowing, focus, 1 mg: “10 days on 1mg oral pinealon. Here's my experience so far: - Complete excavation of brain fog. I wake up in the morning and don't have to lay in bed for 30 minutes or meditate to lift it” — [@pnickdurham on X](https://x.com/pnickdurham/status/2048934953472184649)
- Glowing, focus: “I’m running pinealon in AM, and epitalon before bed and I’m shocked at the difference in mental quickness, and sleep quality. I didn’t even have issues prior but this is next level.” — [@theNOBSdentist on X](https://x.com/theNOBSdentist/status/2035927874536902929)
- Glowing, sleep: “Pinealon was the first peptide that was lifesaving for me at work.” — [@PepMariner on X](https://x.com/PepMariner/status/2114243479790600309)
- Glowing, sleep: “This time I combined with Pinealon, and to be honest with y’all I’m sleeping like I am a 25-year-old coming off of an ICU call shift. I wake up refreshed and it’s amazing.” — [@RupaliChadhaMD on X](https://x.com/RupaliChadhaMD/status/2113986497150091585)
- Glowing, sleep, 1 mg every morning: “The data backs up my anecdotal experience of significantly better sleep.” — [r/Biohackers](https://www.reddit.com/r/Biohackers/comments/1tjvmsh/epitalon_pinealon_2_week_data/)

## Cheapest in Europe

- [Condor Research](https://condorresearch.com/product/pinealon-capsules/) (SK): Pinealon Capsules 60 x 10mg, €125, €0.21/mg
- [Penchant Bio](https://penchant.bio/products/pinealon-spray) (GB): Pinealon spray 12 mL at 10 mg/mL (1 mg/press), €32, €0.27/mg
- [Semax Polska](https://semaxpolska.com/en/pinealon-60-mg/) (PL): Pinealon, 60 mg, €45, €0.75/mg (also contains 5 mg GHK-Cu, judged as [GHK-Cu (injectable)](https://peprank.xyz/peptides/ghk-cu-injectable) since the nasal route is systemic: Strict Avoid · Balanced Avoid · Evidence only Caution)
- [CertaPeptides](https://certapeptides.com/shop/pinealon) (RO): Pinealon 20mg, €71, €3.55/mg (contents not stated on the page)
- [CertaPeptides](https://certapeptides.com/shop/pinealon) (RO): Pinealon 10mg, €40, €4.00/mg (contents not stated on the page)

## Studies

- [Khavinson et al. 2011: Pinealon increases cell viability (Rejuvenation Research)](https://pubmed.ncbi.nlm.nih.gov/21978084/) (in-vitro, 2011): Reduced free-radical build-up and necrotic death in neurons and PC12 cells, and shifted the cell cycle at higher concentrations.
- [Arutjunyan et al. 2012: Pinealon protects rat offspring from prenatal hyperhomocysteinemia](https://pubmed.ncbi.nlm.nih.gov/22567179/) (animal, 2012): Given to pregnant rats with high homocysteine, it improved the offspring's learning and their neurons' resistance to oxidative stress.
- [Meshchaninov et al. 2015: Pinealon and Vesugen in older patients with organic brain syndrome (Russian)](https://pubmed.ncbi.nlm.nih.gov/26390612/) (open-label, n=32, 2015): Biological-age markers improved, alongside a pro-oxidant signal and suppressed blood stem cells; Vesugen did better than Pinealon.
- [Bashkireva & Artamonova 2012: peptide correction of neurotic disorders in truck drivers (Russian)](https://pubmed.ncbi.nlm.nih.gov/23734521/) (observational, 2012): Bioregulator courses, best with Pinealon plus Vesugen, improved stress and mood scores; the abstract gives little detail on the peptide arm.
- [Khavinson et al. 2020: EDR peptide and gene expression in Alzheimer's disease (review)](https://pubmed.ncbi.nlm.nih.gov/33396470/) (review, 2020): Proposes that EDR enters cells and binds DNA and histones to regulate neuronal genes; the evidence comes almost entirely from the same group.

## Sources

- [Khavinson et al. 2011: Pinealon increases cell viability (Rejuvenation Research)](https://doi.org/10.1089/rej.2011.1172)
- [EDR peptide: possible mechanism of gene expression (2020 review)](https://pmc.ncbi.nlm.nih.gov/articles/PMC7795577/)