GLP-1 agonists (semaglutide, tirzepatide, retatrutide) user reports (56)

🌷 my reta update 🤍 started: february 10, 2026 240lbs vs 133lbs (108 kg vs 60kg) 107lbs lost (48kg lost)

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• 6.6K6,632 likes

Zepbound (tirzepitide) saved my life. PCOS (now PMOS) made me legitimately suicidal. I gained 50 lbs in a year in 2024. Lost my hair a little. Was prediabetic (it harms your insulin levels). It would yo-yo and back again. I tried surgery, peels, everything just to maintain. The drug is a miracle.

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• 3.1K3,086 likes

In 2022 I was given ozempic, I was on it for 2 years and not one pound lost. In mid 2024 I was given ozempic Mounjaro and in 2025 the weight finally started coming off so slowly that I didn’t even notice.

• 1.9K1,856 points
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I've been trying Retatrutide for 3 weeks. It is insane. I experience zero "food noise" during the day. No desire to eat sugar or drink alcohol. Just don't want it. Food is just fuel. That is the extent of it. My mental clarity is v high.

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• 1.6K1,577 likes

I had prayed to a god I don’t believe in that this medicine would work for my alcoholism and for weight loss. Since that first shot, I haven’t had a single craving. I’ve also lost 110lbs.

• 1.4K1,436 points
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I started in June of last year, and as of today, I am finally at my goal weight! I feel like an entirely new person. Side effects were minimal (mostly nausea in the very beginning, some constipation but that was managed with a general over the counter magnesium supplement.)

• 1.4K1,386 points
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I was one of those people that felt it right away, like within hours. My food noise was no longer present, and I found myself forgetting about what snacks were in the pantry/fridge.

• 1.3K1,276 points
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Fast forward 6 months and I’m now almost 65 lbs down. I’m currently taking 2.25 mg of reta and still making progress while also hitting the gym consistently.

• 1.1K1,079 points
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I am currently 134.4 pounds and have been since end of June/beginning of July. The progress picture (taken just this weekend) speaks for itself.

• 855855 points
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From my 334lb starting weight, that's just over 35lbs lost since October. These drugs are a miracle, and once it's established they won't give us all cancer or something, they are Nobel Prize-worthy. The price stings for sure.

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• 513513 likes

When I say my life has been changed I mean it. Reta works. I don’t obsess over food anymore and no longer have the desire to use drugs.

• 407407 points
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been on reta 10 months now and ive lost 54kg(120) going from 148kg(326lbs) to 94kg(207lbs) for a good few months now ive completely changed my relationship with food, i no longer use food as coping mechanism

• 386386 points
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I've been on Ozempic for 3 years now. I'm almost 70 years old & have never felt so good in my life. if doctors allow, I don't plan to quit I still enjoy food but my approach is radically different: I can stop!

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• 375375 likes

Since starting Wegovy in June, I’m down from 227lbs to 180lbs (47lbs), and honestly the improvements go way beyond the scale

• 302302 points
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Ozempic gets a bad review and it saved my life. I’m not on it anymore, but it taught me how to eat good and healthy. I lost 110 lbs and It taught me how to control my appetite.

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• 212212 likes

I've been taking semaglutide for ~4 weeks now and I can't believe how amazing it has been. I've lost 8lb so far, but even if I wasn't losing weight I think I would still take it just for the mental benefits.

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• 172172 likes

I've been taking Mounjaro for 3 years now, at 15mg dose since April 24, and no stomach or other internal issues. My A1C is now 5.2 to 5.4 and I've lost 135 pounds. Though I did hit plateaus in weight loss that increased protein intake kicked off the weight loss again.

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• 3232 likes

I've lost 60 lbs which I have never been able to do before and have tried so many things over the years. But more importantly-- and probably the reason I will stay on it long term even though I am at goal--is the freedom from food noise.

• 77 points
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I was prescribed Mounjaro in August 2024 after my AIC came back as 10.6. I was terrified of the drug. Two years later I’m doing amazing and hope I can stay on it forever. I’ve lost 162 lbs to reach my ideal body weight and my AIC is 5.

• 66 points
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I tried Ozempic about 1.5 years ago because I love testing new things. 2 weeks in my immediate thought was: this will help cure alcoholism. Could feel it.

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• 2.7K2,677 likes

The side effect that effected me most was the nausea and diarrhea. When I would hit a certain dose level (I cant remember the number), I would get this horrible nausea and diahrea combo.

• 859859 points
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The food noise is GONE. I didn’t realize how much I ate out of boredom until I wasn’t doing it anymore.

• 537537 points
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I've been injecting Zepbound weekly for 10 months and painlessly lost 30 pounds with zero negative side effects and many positive ones. Some people do have negative side effects.

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• 532532 likes

A Long Covid true story: Almost 3 mos. ago I started tirzepatide (aka Zepbound, a glp-1 med) to lose 25 lbs. I'm not diabetic. The day after I started it my tremors disappeared. They've not returned.

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• 525525 likes

16 weeks of Reta. Down about 40 lbs. Finally, under 290. Haven't seen that number in about 6 years. 6 mg a week has been a good ride so far.

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• 161161 likes

I’m still in the lowest dose. I’m glad that I’m losing weight, but the food noise being gone is the best part. I would gladly stay at this level and not lose another pound for just that.

• 3636 points
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After seven weeks on Ozempic, I've lost 24 lbs. Despite unpleasant side effects such as nausea, fatigue, and heartburn, I've persevered and am thrilled with the outcome.

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• 2626 likes

I was on 2.5mg for one month, then 5mg for 5 months. I lost 44lbs in total. Moved up to 7.5mg a month ago and am not losing any weight at all.

• 1313 points
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Half my hair is a bob just above my shoulders and the other half growing out into a pixie. I don’t take anything, it’s just coming back on its own now that my weight is stable.

• 295295 points
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Been on 6mg Reta for a while now. The effects started to dull recently, leading me to believe my current kit was a dud. Sunday I said fuck it, drew 8mg and pinned. Yesterday I threw up eating a PB&J, my first calories of the day.

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• 243243 likes

Side effects: • RHR went up • HRV tanked • Diarrhoea during dose changes • Sulphur burps in the first 2-3 months ... Conclusion: Great results with considerable side effects This is the only GLP1 where I observed consistent fat loss

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• 7575 likes

Semaglutide did nothing for weight loss but I'm no longer on BP medication and my blood sugar plummeted over the course of a year. Tirzepatide however, DID have a measurable effect on weight.

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• 5151 likes

Anecdotal but semaglutide did nothing for me but nasty side effects whereas tirzepatide has been extremely helpful.

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• 5050 likes

Switched over from tzt, and I haven't slept well in 8 months. Started at. 5. Moved up to 2.5 eventually. Wake up every night cannot sleep past 11pm-1am wake up like clockwork.

• 1010 points
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I have zero side effects but I also have zero weight loss. But my a1c is fantastic.

• 66 points
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I have kept going, with a feeling of mild nausea most days plus a feeling of wanting to burp. Weight loss has slowed significantly but down 10 pounds in 16 weeks.

• 55 points
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its insane how people are on this Ozempic fad kick, like its a miracle drug. it literally did nothing for me. i dropped 50 pounds as soon as i started doing fasting/ one meal a day regularly.

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• 116116 likes

(Yes I already tried semaglutide and tirzepatide, along with two dozen other things that didn't work. I am currently eating 700cal/day for 1 out of every 3 months to counteract the weight gain from eating enough to think in the other 2 months.

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• 104104 likes

I (36F) started Wegovy 8 months ago and worked up to the highest dosage and stayed there. I have weeks where I’ll maybe lose a pound here or there, but then I’ll gain it back, ultimately a net zero loss.

• 6565 points
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Same thing for me, I was on Mounjaro for 2 years and and loat a significant amount just existing, switched over to ozempic and nothing. Eating the same, exercise the same, it just doesn't work for some people.

• 1313 points
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I started my journey at 178 lbs and now at 173 lbs. So barely 5 lbs in 9 months.

• 1111 points
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I started at 1 mg, felt nothing. Went up to 2 mg, still nothing. Then 3 mg, same situation no appetite suppression, no noticeable effects at all.

• 22 points
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I’m stuck in bed with severe fatigue, muscle pain, dizziness and when I stand up, I can’t support my own body weight. I don’t think it’s my lupus kicking off anymore. I suspect it’s the mounjaro. I hope not…because it’s controlling my pcos.

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• 9999 likes

I would have to "sleep" 12 hours to get 7.5 hours of actual sleep. And even then, the quality was not there. 20 sleep disruptions in a span of 6 hours of sleep.

• 2525 points
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I literally puke my guts out, every single day. I’m over it, it’s not even helping me lose weight like zepbound did.

• 1313 points
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I tried ozempic and wegovi first and after one month each it made me very mean.

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• 88 likes

On Ozempic in four months, I lost 18 pounds but my doctor forgot to give me the protein protocol so when I came in for my weighing, he also did a muscle analysis and said that 12 pounds out of the 18 that I lost was muscle.

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• 55 likes

Concern about my vision was one of the reasons I stopped taking Zepbound. I had almost daily flashes of light in the corners of my eyes toward the end of those five weeks of using it.

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• 1.8K1,842 likes

Last Thursday, with slight forgetfulness on my side, I jabbed 14mg of Reta .... well I've had a few side effects, sickness, unable to eat ANYTHING, itchy skin that feels like sunburn and it's still ongoing now.

• 394394 points
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Took myself to the ER at 3 am assuming this was constipation again and I’d be embarrassed for even going. Turns out, it was not constipation. It was my gallbladder that was super inflamed, and now I need emergency surgery to remove it.

• 169169 points
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Just got my living room couch cleaned because I projectile vomited all over it yesterday after taking a 4mg Reta dose (first time taking any GLP, 8x the recommended starting dose)

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• 155155 likes

Was just hospitalized for severe palpitations/ blood pressure spikes and drops after taking Reta , put me in svt and was administered adenosine 2x to knock me back . Didn’t work , I’ve been on beta blockers and haven’t taken it in weeks nor do I intend to .

• 66 points
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But one dose (1.5mg) gave me afib and sent me to the cardiologist.

• 44 points
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2023, I was on #Semaglutide to lower A1C. SEVERE GASTROPARESIS!!! Rushed by ambulance, hospitalized! NEVER AGAIN!

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• 44 likes

It worked in so much as I lost 30lbs in a month. Why? Because I did nothing but vomit the entire month. After a few months of this, my endo and I decided to move on.

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• 22 likes

Results? Amylaze levels over 2000 U/L. So I'm here, IV'ed since yesterday with painkillers, hydration and other stuff. So this is the end of MJ journey

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