PepRank

Bovine colostrum

47%positive24 reports

Also: first milk · ARMRA / Cowboy Colostrum / WonderCow · goat or sheep colostrum

CautionSupplementImmuneOral

Cow's first milk: immunoglobulins, lactoferrin and growth-factor peptides for gut lining and fewer colds.

mixture: whole colostrum (immunoglobulins, lactoferrin, growth factors); no single sequence

#10 of 23 supplements · updated
Access
Supplement
Cost / month
≈ €28–56
at 1–2 g/day · Supersmart · €0.93/g
OralFelt in 2 days – 2 weeks

Builds over days or weeks of regular use rather than with each dose.

24 user reports
Glowing 7Positive 4Mixed 3Nothing 4Negative 2Bad reaction 4
  • r/SIBO· · 126 upvotesOriginal ↗

    I could cry tears of joy, I never thought I’d feel like this again, like my body can move and I can eat without immense discomfort. My body looks so much younger and stronger than it’s been in years. I’ve only been taking it for a couple weeks.

    GlowingOral · a couple of weeks

    SIBO; NOW capsules then powder

  • r/SIBO· · 43 upvotesOriginal ↗

    Colostrum cured a skin disease which i was suffering from for more than a decade. Ive had countless of doctor visits, blood tests, skin samples, tried different medications which either did nothing or helped temporarily. I took colostrum for 2 weeks and my skin completely healed.

    GlowingSkin & hair · Oral · 2 weeks

    unnamed chronic skin condition unresponsive to prescribed treatments

  • r/Biohackers· · 27 upvotesOriginal ↗

    I took it a few years ago and it did not do anything heroic or even noticeable. I had been optimistic about it because it sounded potent and promising once I read what it was...

    NothingOral

Users report
Loud fans in r/SIBO, r/ibs and r/Gastritis: firmer, normal stools after years of IBS-D, less bloating, coming off acid blockers, and long-term users with low IgG who say they stopped catching colds. Gains often appear within days but in several reports fade after one to two months. About a fifth notice nothing after months, even on expensive brands, and a similar share report reactions: hives or itching that returned on rechallenge, bloating and gas (lactose), constipation, and a recurring 'unexplained weight gain' thread. The category is heavily marketed (ARMRA, influencer brands), so glowing branded posts deserve some scepticism. Felt nothing: ~15-20% of reports.
Best effects
Normal, firmer stools in IBS-D · less bloating and stomach upset · fewer colds / upper-respiratory infections · faster workout recovery (some) · less hair shedding (some)
Downsides
Bloating, gas, constipation (lactose and dairy protein) · itchy rash or hives in a minority · unexplained weight gain / puffiness reported by several users · benefit fades after 1-2 months for some · expensive premium brands
Watch
Dairy-protein allergy: hives that recur on rechallenge and one report of airway swelling; contraindicated in milk allergy · contains IGF-1: one small trial found a rise in serum IGF-1, a larger dose in another found none; a theoretical growth-factor concern that has not been confirmed at supplement doses
Evidence
Human RCTs — Gut permeability under NSAIDs and heavy exercise, upper-respiratory symptoms in athletes; a meta-analysis of 5 small, mostly biased trials
Caveat
Kept as mostly-clean: it is a food (the first milk of a cow) with a long record of safe use, and the IGF-1 worry rests on one 9-person trial that a larger dose failed to reproduce, against ordinary dairy's own IGF-1 content. The real exposures are allergy to bovine proteins, where hives that return on rechallenge mean stopping, and lactose. Reddit's weight-gain and liver-enzyme reports are single anecdotes without a mechanism. The trial evidence comes largely from one group (Playford and Marchbank), and the athlete trials are small.
Typical use
1-2 g/day in capsules (studies used up to 20-60 g/day of powder), on an empty stomach or with a meal; avoid hot drinks; start low if lactose-sensitive.
Getting it
Widely sold as capsules and powder; cheap commodity capsules (NOW, California Gold) and premium marketed powders (ARMRA) contain the same class of product. Lactose and IgG content vary by brand.
Stacked with
Zinc carnosine (polaprezinc): combined in the Davison 2016 exercise gut-permeability trial, with an additive effect · lactoferrin: often added by SIBO and IBS users; it is one of colostrum's own active proteins · lactase: lactose-intolerant users take it with lactase to reduce gas

User reports 25

  • r/SIBO· · 126 upvotesOriginal ↗

    I could cry tears of joy, I never thought I’d feel like this again, like my body can move and I can eat without immense discomfort. My body looks so much younger and stronger than it’s been in years. I’ve only been taking it for a couple weeks.

    GlowingOral · a couple of weeks

    SIBO; NOW capsules then powder

  • r/SIBO· · 43 upvotesOriginal ↗

    Colostrum cured a skin disease which i was suffering from for more than a decade. Ive had countless of doctor visits, blood tests, skin samples, tried different medications which either did nothing or helped temporarily. I took colostrum for 2 weeks and my skin completely healed.

    GlowingSkin & hair · Oral · 2 weeks

    unnamed chronic skin condition unresponsive to prescribed treatments

  • r/Gastritis· · 30 upvotesOriginal ↗

    Since starting colostrum, I haven’t needed Nexium, Pepcid, or any other supplements. I’ve even tested it with known triggers like pasta sauce and hot sauce, and had no issues.

    Glowingone dose a day · Oral

    two years of on-off gastritis; taken with a 'gut assist' product

  • r/Biohackers· · 14 upvotesOriginal ↗

    It was the only thing that helped with bloating and improved my digestion dramatically. I took morning/night on empty stomach...500mg

    Glowing500 mg morning and night on an empty stomach · Oral

    chronic bloating

  • r/Supplements· · 6 upvotesOriginal ↗

    I have been taking it for 5 years. I always had low igg levels and used to get sick daily. However, ever since taking it, I’m the only one among friends and family who hasn’t been sick in years.

    GlowingImmune · Oral · 5 years

    low IgG, previously frequently ill

  • r/Supplements· · 3 upvotesOriginal ↗

    2 scoops of armra every morning first thing has completely transformed my gut and I have perfect poops now. It’s crazy. I tried everything under the sun, probiotics, fiber, elimination diets, dairy, gluten. Nothing has been such a huge game changer as colostrum.

    Glowing2 scoops ARMRA every morning · Oral

    32-year-old, loose irregular stools for over 10 years; probiotics, fibre and elimination diets had failed

  • r/Supplements· · 2 upvotesOriginal ↗

    I have been taking for about 4 months and my bloating and IBS symptoms are gone. My bowel movements are normal first time in years . It helped with joint pain in my fingers as well!

    GlowingOrgain colostrum with pro- and prebiotics · Oral · about 4 months

    IBS; product also contains probiotics

  • r/Biohackers· · 25 upvotesOriginal ↗

    i took it for 6 months and noticed my hair wasn’t thinning as much i have before/ after photos. and i didn’t get sick as it was winter and everyone around me was sick constantly.

    PositiveImmune · ARMRA powder twice a day · Oral · 6 months

    during IVF prep, alongside prenatals, hormone shots, acupuncture and herbs, so heavily confounded

  • r/SIBO· · 20 upvotesOriginal ↗

    I took a single pill and the reaction was almost immediate a really unpleasant day feeling feverish and just generally terrible, but I felt fine the next day and I have not had any symptoms since!

    Positive2-3 capsules a day · Oral · about a week

    SIBO; only a week in

  • r/Supplements· · 13 upvotesOriginal ↗

    I have a very sensitive stomach and colostrum helps my stomach be less upset. I take one in the AM on an empty stomach and one before I go to bed so 1,000mg total.

    Positive500 mg capsule morning (empty stomach) and bedtime, iHerb California Gold · Oral

    sensitive stomach; cheap capsules worked, sceptical of premium brands

  • r/Supplements· · 11 upvotesOriginal ↗

    I've taken it for almost two months. Hair and nails are growing at a more rapid pace. Quicker recovery from workouts. Increased muscle building, allowing for more rapid progressive overload.

    PositiveRecovery · Oral · almost 2 months

    lifter

  • r/Supplements· · 20 upvotesOriginal ↗

    While they do help my stomach feel more settled, I have noticed that they also seem to aggravate my IBS-C. Another side effect that I am noticing is rapid weight gain. As soon as I go off of them I 'deflate' and am back to a more normal weight.

    MixedOral

    tried Jarrow and Symbiotics brands for immunity and gut

  • r/SIBO· · 4 upvotesOriginal ↗

    Colostrum was one of the best things to help with my gut illness, but it only lasted for about 2 months before things started to degrade again.

    MixedOral · about 2 months

    dysbiosis

  • r/ibs· · 3 upvotesOriginal ↗

    Unfortunately not. It seemed to have worked for a month and then my issues started up again.

    MixedOral · about a month

    IBS-D, following up on a 'Colostrum. Try it!' thread

  • r/Biohackers· · 27 upvotesOriginal ↗

    I took it a few years ago and it did not do anything heroic or even noticeable. I had been optimistic about it because it sounded potent and promising once I read what it was...

    NothingOral

  • r/Biohackers· · 3 upvotesOriginal ↗

    I took amra colostrum for 3 months and didn’t notice a thing

    NothingARMRA · Oral · 3 months

  • r/Supplements· · 3 upvotesOriginal ↗

    I’ve been taking it for a few months - haven’t noticed a my difference.

    NothingOral · a few months

  • r/Supplements· · 2 upvotesOriginal ↗

    I took mine daily for 2 months and noticed no difference. I’m stopping once this container is gone…

    NothingOral · 2 months

  • r/Supplements· · 3 upvotesOriginal ↗

    I started taking Cowboy Colostrum 2 months now every other day), and have gained 10lbs. I usually lose weight in the summer- and this has wrecked my stomach, my acne is worse and now I don’t fit in my clothes.

    NegativeCowboy Colostrum every other day · Oral · 2 months

  • r/SIBO· · 2 upvotesOriginal ↗

    I have tried some but I am lactose intolerant so it gives me terrible gas.

    NegativeOral

    lactose intolerant

  • r/Supplements· · 10 upvotesOriginal ↗

    I am not lactose intolerant and had no GI issues while taking it but noticed after several days that I started developing severe itching and moderate burning on several areas of my body. My lower legs are especially bad

    Bad reactionARMRA · Oral · about a week, twice

    not lactose intolerant; reaction appeared on both courses

  • r/Supplements· · 4 upvotesOriginal ↗

    It caused me right side / back pain, constipation, tan stool and elevated liver enzymes I took it fine for a month but caused excess mucus in stool didn’t think too much of it, did the second month and it’s a huge no go for me now

    Bad reactionOral · 2 months

    fine in month one, problems in month two; self-attributed

  • r/Supplements· · 3 upvotesOriginal ↗

    I've been taking colostrum the last 5 days and I feel great but it does cause my airways to swell. I know that this is a herx symptom. I do not have an allergy to milk.

    Bad reactionOral · 5 days

    leaky gut and mould illness, post-COVID breathlessness; read airway swelling as a 'herx', commenters told her to stop

  • r/Supplements· · 2 upvotesOriginal ↗

    I started taking Armra Colostrum about a week ago. I have been severely bloated, nauseated like a hangover, I've had intense stomach pain (even woke me up in the night), constipation, back pain, a feeling like heartburn, I wanted to cry for no reason and headaches!

    Bad reactionARMRA · Oral · about a week

  • r/Supplements· · 112 upvotesOriginal ↗

    I've been trying colostrum everyday for 30 days, gradually increasing from 400mg to 5.2g, originally to improve my gut health... but I had other benefits:

    Positive400 mg rising to 5.2 g/day · Oral · 30 days · vendor-adjacent

    post promotes the author's YouTube video of the experiment

Safety

Tier by safety barStrict CautionBalanced CautionEvidence only Caution

Seen harmMechanismData gapSilent harmProduct

Seen harm 1/3
No serious events in the small RCTs; first-hand reports include airway swelling (in someone without known milk allergy) and raised liver enzymes after a second month, isolated and unverified. Anaphylaxis in milk allergy is a contraindication. r/Supplements: colostrum causing airway swelling ↗r/Supplements: colostrum weird side effects (raised liver enzymes, severe GI reactions) ↗Anaphylaxis to a bovine-colostrum cream in a milk-allergic teenager (PubMed 29549703) ↗
Mechanism 1/3
Contains IGF-1, but at supplement doses most studies, including 60 g/day for four weeks, found no rise in serum IGF-1, so the growth-factor concern is weak. Kuipers et al. 2002: 60 g/day colostrum did not raise serum IGF-1 (PubMed 12093430) ↗Review: balance of evidence does not support a systemic IGF-1 rise from oral colostrum (PubMed 34073917) ↗
Data gap 1/3
A traditional food with long supplement use, but the RCTs are small (a five-trial meta-analysis of 152 people) and largely from one group, with no formal safety assessment. Jones et al. 2016: colostrum and upper-respiratory symptoms, meta-analysis of 5 small RCTs ↗
Silent harm 1/3
Allergic and GI reactions appear within days; the isolated liver-enzyme report would show only on a blood test. r/Supplements: colostrum weird side effects (raised liver enzymes, severe GI reactions) ↗
Product 0/3
OTC capsules and powders taken orally, from commodity to premium brands.
Never if
Cow's milk allergy · Lactose intolerance (most products contain lactose) · Competitive athletes (WADA advises against it)

Where to buy 1 in Europe · 2 total

ShopFormPricePer mgTesting
iHerbUScapsules · 60000 mg€23€0.38/gNo public tests
SupersmartEU · LUcapsules · 30000 mg€28€0.93/gOwn COA

Studies 6

Sources 1

More in Gut all 6 →

  1. 1KPV KPV (3 residues) Caution Oral / Topical / Injection≈ €31–61 / month58%positive47 reportsAnti-inflammatory alpha-MSH fragment for gut, skin and allergy inflammation; animal data only.
  2. 2Larazotide GGVLVQPG (8 residues) Clean Oral≈ €54–140 / month56%positive6 reportsTight-junction (zonulin) blocker trialled for celiac; very safe, but efficacy failed phase 3.
  3. 3Polaprezinc (zinc L-carnosine) AH (2 residues) ExcludedSupplement Oral≈ €32 / month54%positive25 reportsJapanese ulcer drug sold as a supplement; the go-to oral 'stomach lining' option for gastritis.
  4. 4Plecanatide Excluded Oral≈ €540–650 / month45%positive25 reportsApproved uroguanylin-like GC-C agonist tablet for constipation and IBS-C; linaclotide's sibling.The label warns of severe diarrhoea (0.6-1% in trials, most within the first days) with instructions to stop and rehydrate, and Reddit users describe days of watery diarrhoea leaving them badly dehydrated. Its sibling linaclotide has post-marketing hospitalisations for the same harm. It is obvious and stops when the drug does, so under a doctor it is a reasonable constipation treatment, but it is a real route to serious harm and does not belong on a clean wellness list.
  5. 5Linaclotide Excluded Oral≈ €450 / month45%positive25 reportsApproved gut-only GC-C agonist pill for IBS-C and constipation; works for many, often too well.The label warns of severe diarrhoea (2% in trials), and post-marketing reports describe dehydration with fainting, low blood pressure and low potassium or sodium that needed IV fluids or hospital, plus rare anaphylaxis and angioedema. The harm is obvious at once and stops when the drug does, so under a doctor it is a reasonable IBS-C treatment, but it is a real route to serious harm and does not belong on a clean wellness list.

Sequence beads

Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.

non-polarpolarpositivenegative

Report grades

Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.

GlowingPositiveMixedNothingNegativeBad reaction

% positive

The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.

Researcher estimate

No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.

Safety tier

Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.

Safety bar

The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.

Seen harm

Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.

Mechanism

A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.

Data gap

How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.

Silent harm

Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.

Product

The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.

Evidence

The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.

Access

How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.

Price per month

Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.

Dose users report

The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.

Testing

Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.

Added peptide

Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.