I am on week 5 of a once weekly Dihexa cycle. So far I have noticed major improvements in athletic ability in rock climbing / basketball & ability to learn to drive a Truck and remember things needed to pass the written tests in CDL school.
GlowingMemory · 10 mg once weekly in DMSO · Topical · 8-week cycle
It is super-effective for increasing memory acquisition (especially for language or stuff like programming), so effective that I have to avoid filling my brain with trash information for the duration of effects.
Dihexa causes additional flatness. Ketamine can help with apathy and anhedonia.
NegativeMood
anhedonia; confirms in a reply it was "strongly so" for them
Strict case
Activates the oncogenic HGF/c-Met pathway, has no human safety data, and its foundational studies are under expressions of concern.
Users report
Polarised: many report energy, faster learning, recall and even chess-rating gains within hours of a dose; others feel nothing even at 30 mg, perhaps 15-25%. Side effects are frequent: insomnia or 3 am waking, or the opposite (exhaustion, dozing off), anger/irritability and emotional flattening. One user reports permanent language interference after months of use and one heard voices falling asleep; commenters also warn of 'aberrant learning' and the cancer mechanism.
Best effects
Energy and mental clarity · faster learning/recall · effects persist between doses (long half-life)
Downsides
Irritability/anger · no effect for many · dosing confusion across routes
Watch
Acts on the HGF/c-Met pathway, a well-known oncogenic driver (tumour growth, invasion, angiogenesis); no carcinogenicity data · FDA found no human exposure data at all · the founding research (Harding/Athira) received expressions of concern; the related drug fosgonimeton failed its phase 2/3 Alzheimer's trial (2024) · theoretical maladaptive plasticity, made worse when stacked with stimulants
Evidence
Animal only
Typical use
5-20 mg/day oral or transdermal (community), often intermittent. Users report 2.6–4.9 mg/day (median 4.3 mg, n=6).
Getting it
Research-chemical and peptide vendors sell powder, capsules and DMSO/transdermal solutions; some US telehealth clinics route it through compounding pharmacies (one user paid $355 for 30 days of capsules) despite its FDA Category 2 status.
Stacked with
Modafinil or ADHD stimulants: Commonly combined for study sessions; NooTopics regulars call pairing a plasticity drug with stimulants reckless. · Semax / Cerebrolysin / P21: Grouped in "brain repair" stacks for TBI or burnout, usually run one at a time to tell effects apart. · Eutropoflavin or tropoflavin: TrkB agonists stacked with it by chess and memory self-testers.
I am on week 5 of a once weekly Dihexa cycle. So far I have noticed major improvements in athletic ability in rock climbing / basketball & ability to learn to drive a Truck and remember things needed to pass the written tests in CDL school.
GlowingMemory · 10 mg once weekly in DMSO · Topical · 8-week cycle
It is super-effective for increasing memory acquisition (especially for language or stuff like programming), so effective that I have to avoid filling my brain with trash information for the duration of effects.
I have been taking Dihexa for the past month. Started at 10mg every other day but dropped it to 5 mg after first week. It’s fucking amazing. It’s giving me energy and i can think so much clearer..
GlowingEnergy · 10 mg every other day, then 5 mg · Oral · 1 month
Some times headaches, normally just due to a lack of Choline so I just eat eggs and it goes away, but past that its just insane memory and learning with unbreakable focus, I learned LUA In a week, no joke.
GlowingMemory · 2.5 mg with 5 mg Adderall, as needed · Oral · weeks (5 on/2 off on school days)
I feel supreme! My mood went from somber and lazy within an hour or so. I mopped my floors twice. Lots of happy thoughts and excited to share what happened.
GlowingMood · 5 mg in 20 ml DMSO, 2 sprays per wrist · Topical · single dose
I was smoking pretty much everyone, like 90%+ win rate and 85+% accuracy each match. I dont know if it was the dihexa ... but wow is it subtle because I swear I feel no different at all even now.
I have struggled to sleep on it as it does give me quite a bit of energy. I noticed immediately that I was able to focus, understand and remember things much clearer on the first day!
PositiveMemory · 8 mg daily, then every other day · Oral · 2 weeks
I’ve done 180 pill 5mg over a 6 month period. Have seen more improvement than doing 20 years of 45mg dextroamphetamine per day. Had trouble sleeping while taking but didn’t seem to matter like it would on dextro.
It feels like mild adderall. I didn’t feel necessarily “smarter” kinda similar to semax in terms of “intelligence boost”. But what I did have was unlimited mental stamina. I put 7 hours of work in a row with barely any breaks at all except for a quick lunch.
PositiveFocus · 10 mg · Oral · 4 doses over a week
later called it the most effective nootropic they had tried
I tried it myself last year and I could learn things a lot faster. People down vote me for saying it but it's true. Within about 2 or 3 weeks of stopping I was back to baseline
I’ve experienced some clear cognitive effects, but it’s been inconsistent. The first time I took Dihexa (oral, in a fish oil gelcap with DMSO) back in April, the results were insane. Unreal clarity, near-perfect metacognition, and the effect lasted a solid three days before tapering off.
PositiveFocus · up to 5 mg, oral in DMSO or IV · Oral · 7 doses over about 3 months
I lost my mum at a early age and on dihexa I remember things about her that I honestly thought I forgot like the smell of her cooking, childhood games and stuff like that
I felt smarter, emotions dulled, but was very productive and had tunnel vision completing tasks ... It was very intense I felt like my head was heavy almost, insane tunnel vision but this day it wasn’t as good.
MixedFocus · 50 mg · Oral · 3 days
long-COVID and job-loss depression; stacked with Adderall or modafinil
I believe it did work as I felt very clearheaded almost immediately after taking it, but I stopped after less than a week. The substrate that it was dissolved in (DMSO, I believe) gave me such a horrible body odor that my SO told me to stop.
Tried the 8mg and it wiped me out, made me exhausted tired about 2 hours after ingesting. Cut it in half to 4mg, and I am dozing off within about 2 hours.
NegativeRecovery · 8 mg, then 4 mg · Oral
post-concussion syndrome; topical years earlier did little
I used it to study modern hebrew ... I believe it made some permanent engravings in the language areas of my brain; it's produced a substantial amount of interference in my more recent language learning studies and even with my native language English.
Bad reactionMemory · 10 mg/day · about 3 months, 4 h/day of study
It gave me fatigue immediately after the dose. ... One time It made me hear voices in the stage between wake and asleep. I discontinued It After ... Imho It's useless
Bad reactionseveral months, oral and DMSO
Safety
Tier by safety barStrict ExcludedBalanced ExcludedEvidence only Caution
Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.
non-polarpolarpositivenegative
Report grades
Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.
GlowingPositiveMixedNothingNegativeBad reaction
% positive
The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.
Researcher estimate
No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.
Safety tier
Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.
Safety bar
The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.
Seen harm
Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.
Mechanism
A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.
Data gap
How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.
Silent harm
Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.
Product
The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.
Evidence
The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.
Access
How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.
Price per month
Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.
Dose users report
The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.
Testing
Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.
Added peptide
Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.