Holy crap when I took CJC-1295 no DAC and Ipamorelin for 10 weeks it changed my life! I felt like a superhero and my sleep was CURED. I slept like a tank I could get like 10 hours worth of sleep in only 6 and my rem and deep sleep like doubled.
Ipamorelin makes me feel like I'm starving to death. Sermorelin sends me into great sleep and I wake up feeling like I actually slept.
NegativeSleep
preferred sermorelin
Strict case
GH/IGF-1 axis elevation plus repeated anaphylaxis reports, including a coroner-attributed death.
Users report
Better sleep ('magical'), recovery and gradual body recomposition from weeks 6-8, almost always with CJC-1295. About 30-40% see little. Common complaints are hunger, night sweats, raised night heart rate and sleep disruption. Delayed allergic reactions (lumps, then itching, then flushing and breathlessness around week 8) recur. An Australian coroner (Oct 2026) attributed actor Richard Norton's 2025 death to anaphylaxis after CJC-1295/ipamorelin taken above the prescribed dose.
Best effects
Deeper sleep · recovery · slow fat loss / recomposition
Downsides
Hunger · flushing, head rush · water retention · night sweats / disturbed sleep
Watch
GH/IGF-1 axis elevation (glucose, theoretical neoplasm promotion) · Progressive hypersensitivity and anaphylaxis (case reports; coroner-confirmed death 2025, Australia) · FDA notes deaths in an IV ipamorelin gastric-motility study
Evidence
Small human studies — Phase 2 IV for post-operative ileus, failed
Typical use
100-300 mcg subQ 1-3x/day, typically at bedtime fasted, 5 on / 2 off. Users report 140–190 mcg/day (median 160 mcg, n=6).
Getting it
Never approved anywhere and on the FDA's Category 2 list, though some US and Australian anti-aging clinics still prescribe it. Most users buy research vials, usually a premixed CJC-1295/ipamorelin blend.
Stacked with
CJC-1295 (no DAC): The default pairing, usually in one vial; a GHRH plus a ghrelin agonist gives a bigger GH pulse. Most reports on this page are for the combo. · Retatrutide or tirzepatide: The dominant 2026 pattern: GLP-1 for fat loss, CJC/ipa for sleep and muscle retention. Ipamorelin's ghrelin-driven hunger can override the appetite suppression. · Tesamorelin: Tesa/ipa blends are the pricier alternative for belly fat; several users who reacted to CJC moved to tesamorelin, though some then reacted to it as well.
Holy crap when I took CJC-1295 no DAC and Ipamorelin for 10 weeks it changed my life! I felt like a superhero and my sleep was CURED. I slept like a tank I could get like 10 hours worth of sleep in only 6 and my rem and deep sleep like doubled.
Sleep has been magical. Overall weight has been steadily dropping as it was before. What I have noticed is that I am getting more defined. Muscle mass is looking leaner and mid section has been looking tighter.
GlowingSleep · 200 mcg CJC + 200 mcg ipamorelin, 5 on / 2 off · Injection · 4 weeks
on tirzepatide in a calorie deficit; CJC/ipa combo
in only like 2-3 days, my sleep has been restored, and for once in my life, I am actually getting the sleep I need to function at the highest level. It truly worked very well for me, CJC/IPA in particular ... A bit of a histamine reaction, but nothing that srs imo.
3 weeks ago I added cjc+ipa for body recomp and I love the results. Seeing baby abs + my arms are getting super toned. I have had absolutely no side effects with either besides a bit of manageable fatigue
I started Ipamorelin/CJC-1295 4 weeks ago. Seeing benefits already. I have lost 33 pounds/15% body fat on GLP, now growing muscle and getting waist down below 34 from 40.
I’ve only begun feeling different as of yesterday & today. - Dreaming like crazy - Feel less sluggish in the more - Feel more energetic upon waking (i’m usually a zombie when i wake up) even if I didn’t get my optimal sleep
Only started it to see if it would help with my sleep while I was on reta because I was walking up every night at 3am from a glucose crash and also just generally struggling to fall asleep on the evening. I will say, within days I was sleeping like a rock.
I felt first I was able to at last sleep through the night for the first time in a very long time. Then I went to feeling overall better at the gym. My skin also looks smoother
PositiveSleep · 10 units each, nightly, 5 on / 2 off · Injection · 1 month
I was running a high dose of IPA at 333 mcg three times a day for five days and then the following 10 days would just do 500 mcg at night. huge sperm load and athletic recovery, strength, endurance.
PositiveRecovery · 333 mcg 3x/day for 5 days, then 500 mcg nightly · Injection
I've taken cjc1295 and Ipamorelin without DAC for 12 weeks and have experienced zero side effects but a ton of benefits including significant hypertrophy.
Had low test and thyroid due to stress. Hopped on CJC/Ipamorelin. Fixed everything. I’m now on my 3rd cycle of CJC and up around 10 lbs of muscle as well.
After a few weeks my appetite has stabilized again which is great and I’ve been able to recover better allowing me to add in an extra strength day to my half marathon training - overall I’m a fan
PositiveRecovery · several weeks
27-year-old woman on low-dose retatrutide, half-marathon training; CJC/ipa combo
I was using peptides - ipamorelin and CJC1295– and was sleeping better but stopped for a little bit and I couldn’t sleep very well. I just reordered some
I actually don't feel better recovered/sleep better- I really feel more tired. BUT in 4 weeks I dropped about 3lbs of fat and gained 1.3 of muscle (42 y/o F)
MixedMetabolic · 4 weeks
42-year-old woman also on GLOW, retatrutide and HRT; CJC/ipa combo
strength is increasing. lat pulldowns, strict press, bench press, back squat are all up a bit from last week. - sleep is kinda messed up. My deep sleep has been ~90 minutes. Normally I hit 3 hours inside an 8 hour sleep cycle.
The very first night I took it I had the best night sleep ever. Every single day since then I’ve literally felt or seen no difference. I’m entering week 5
Had to pull Ipamorelin out of my stack, it was clogging up the bowels more than GLP3 was already. +the water retention I was getting was not comfortable.
since I got another ipamorelin vial I’ve had two nights where I’ve woken up with a high heart rate of 90-100 for like an hour and a quarter accompanied with nausea and/or vomiting
Negative
started with a new ipamorelin vial; CJC/ipa stopped
Tesamorelin made me have a anaphylatic episode Saturday night...1.75 mg and 500 mcg of ipamorelin...same vial I have used 5 times this week....4 weeks into the cycle...Wonder why??
Bad reaction500 mcg with 1.75 mg tesamorelin · Injection · 4 weeks
tesamorelin + ipamorelin; same vial used 5 times that week
Within minutes, my entire body was intensely itchy even felt like I was itching internally. My lips began swelling, my vision became blurry, and I developed some tightness in my throat
Bad reactionRecovery · ~4 months over two cycles
mid-20s athlete; CJC/ipa combo, also using a KGLOW blend; reaction subsided in 30-45 minutes without epinephrine
Well, I took it a second time, and went into full-blown anaphylaxis. Full body itching, swollen tongue and lips, high heart rate and low blood pressure. I passed out, my wife called 911, and I woke up in the ICU on an epinephrine infusion for 24 hours.
Took cjc and ipamorelin and had an insane reaction. Tingles all over my body, lips, face and throat swollen, and broke out in mild hives. After that is said fuck that.
Loved them. Put 20lbs on cjc ipamorelin in 6 months and it was great. Then came the intense histamine reactions on the 2nd go around with chest tightness, sob, flushing all of it. Not even remotely worth it
Bad reactionRecovery · 6 months, then a second course
Within the first two weeks of this GH secretagogue protocol, my deep sleep cycles (monitored via wearable) increased by nearly 40%. I’m no longer waking up at 3 AM with cortisol spikes.
Just finished my first 5 week CJC/IPA cycle, and I honestly did not expect the results to be as good as they were. Stacking CJC/IPA with Reta and MOTS-C had the fat flying off while helping me retain muscle surprisingly well.
PositiveMetabolic · 5 weeks · vendor-adjacent
CJC-1295 + ipamorelin stacked with retatrutide and MOTS-c; promotes another peptide account
Safety
Tier by safety barStrict ExcludedBalanced ExcludedEvidence only Excluded
Active cancer or a history of cancer · A history of anaphylaxis · Diabetes or impaired glucose tolerance · Pregnancy or breastfeeding (no human reproductive data)
Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.
non-polarpolarpositivenegative
Report grades
Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.
GlowingPositiveMixedNothingNegativeBad reaction
% positive
The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.
Researcher estimate
No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.
Safety tier
Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.
Safety bar
The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.
Seen harm
Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.
Mechanism
A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.
Data gap
How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.
Silent harm
Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.
Product
The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.
Evidence
The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.
Access
How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.
Price per month
Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.
Dose users report
The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.
Testing
Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.
Added peptide
Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.