Ive tried countless nootropics/drugs in attempt to settle my anxiety without sedation or cognitive/emotional dulling. GB115 not only does that but also subtly uplifts my mood.
The only thoughts in my head were/are relevant, not ruminating. I can do the hard things if I want. (Never could before without extreme stress and anxiety)
i've tried as a once-off on a few occasions, but it was part of a larger stack (ofc) so i don't have an accurate read on it yet. have properly tried a nasal spray and that version was useless.
NothingNasal
earlier once-off doses were inside a larger stack
Users report
Enthusiastic r/NooTopics reports: lower GAD and rumination, 'vacation feeling', no sedation, often after 1-2 weeks of daily use. Fewer threads than Selank and a vendor (Everychem) drives much of the discussion, so treat with some caution; perhaps 25-35% feel little.
Best effects
Less rumination about the future · reduced general anxiety · mild mood lift · no sedation or cognitive dulling
Downsides
Nasal burning (spray) · slow onset (1-2 weeks) · vertigo after months of use (isolated report) · short duration (~4 h)
Evidence
Approved drug — Approved in Russia as Ranquilon; open randomized phase IV trial (2026, n=200) beat fabomotizole on anxiety response (63% vs 49%), mild side effects only. Earlier: uncontrolled pilot in 31 GAD patients.
Caveat
Strictly a peptidomimetic, not a classic peptide. No known harm mechanism, but the evidence base is thin and mostly from the developer institute.
Typical use
2-6 mg/day sublingual/oral in divided doses (clinical pilot used 1-6 mg), or 3-5 sprays/day; cycle after a few months.
Getting it
Approved in Russia as Ranquilon tablets; elsewhere research-chemical nasal sprays, oral solutions and powder.
Stacked with
Selank or NA-Selank: The most discussed pairing for anxiety, used together or situationally. · Modafinil or flmodafinil: Several severe-anxiety users say the combination leaves them energized and able to go out without the stimulant's jitters. · ACD-856: A common r/NooTopics combination for anxiety plus mood and drive; users note it is hard to tell which compound does what.
Ive tried countless nootropics/drugs in attempt to settle my anxiety without sedation or cognitive/emotional dulling. GB115 not only does that but also subtly uplifts my mood.
The only thoughts in my head were/are relevant, not ruminating. I can do the hard things if I want. (Never could before without extreme stress and anxiety)
And when I say most effective what I mean by that zero sedation, no adverse affect on cognitive performance, no abnormal mood. Just like, oh yeah, forgot what just plain normal felt like.
GB115 gives me a mild calming benefit, particularly when I'm feeling stressed or tense. It has more of a passive psychoactivity, akin to CBD, in my experience.
For me verbal fluidity and eye contact was noticeably improved after only 3-5 days of 2-4 sprays a day. The anxiolytic effect took around a week to set in for me
I don't know if I'd say life-changing, but I do notice strong effects. However, I started taking GB-115 at the same time as ACD-856, so it's hard to say with any certainty which compound is causing the effects.
I like it. At first I thought it was a dud not doing much because you won’t really “feel” anything but definitely notice the edge is taken off. Effects seem ti last for a few days after even
GB 115 is the clear winner. That said the effects are quite modest, it would mostly quite my internal monologue which in turn reduced my anxiety slightly — it was far from life changing like others have experienced.
It has a bit of cross talk with opioid receptors so it felt a little happy not just relaxed. Prefer emoxypine during the day or low dose gabapentin closer to bed.
it potentiates stimulants so i take it on the comedown to smooth over the comedown anxiety and also for a perk-me-up tjat doesnt involve more stimulants
It is fairly effective, but fair warning you will probably want to cycle off it for a bit after a couple months, it started causing this weird vertigo for me after a while.
Takes the edge off, 0 euphoria, DOES make me a little... like... less verbally fluent? Not as talkative. But, that beats the fuck out of the anxiety that I'm using it to treat.
i've tried as a once-off on a few occasions, but it was part of a larger stack (ofc) so i don't have an accurate read on it yet. have properly tried a nasal spray and that version was useless.
Only tried the oral russian version of GB for 3 weeks (but only 2mg 2 times per day instead of 3 in the studies) and tbh didn't feel any anxiety relief so I stopped.
Basically I felt drugged or sedated but awake at the same time. My brain felt like scrambled eggs, nothing was making sense and nothing seemed real; insanely disoriented.
Bad reactionabout 1 mg (oral solution) · Oral · single dose
Gb-115 is a bit hard to manage. Takes time to build up in your system to feel it at all, but will also build up too much after a couple months and start giving you vertigo.
Bad reactiona couple of months
Safety
Tier by safety barStrict CautionBalanced CleanEvidence only Clean
Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.
non-polarpolarpositivenegative
Report grades
Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.
GlowingPositiveMixedNothingNegativeBad reaction
% positive
The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.
Researcher estimate
No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.
Safety tier
Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.
Safety bar
The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.
Seen harm
Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.
Mechanism
A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.
Data gap
How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.
Silent harm
Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.
Product
The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.
Evidence
The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.
Access
How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.
Price per month
Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.
Dose users report
The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.
Testing
Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.
Added peptide
Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.