Started selank last month, 0.48mg intranasally once a day and WOW. A social situation that would have me at 7/10 tension is now a 3/10 at most. Physical symptoms - gone.
GlowingSocial · 480 mcg once daily · Nasal · 1 month (later 21 on / 7 off)
From day two I already felt a sober kind of mood fall, becoming a more intense depression as the days passed. I also became withdrawn, socially anxious, frightened and small whilst in public, worthless and hopeless.
Bad reaction1 week
sensitive to serotonergic drugs
Users report
The most glowing reports in this group: a large minority describe social anxiety or rumination 'just gone' within days, several on SSRIs or tapering benzos. Roughly 30-40% report nothing or 'very subtle', and there is a small but recurring tail of bad reactions (anxiety spikes, depressive dip, 'out of it') lasting days to occasionally weeks.
Best effects
Reduced rumination/overthinking · less social anxiety, easier eye contact · calm without sedation · calmer sleep and dreams · helps some taper benzos/SSRIs
Downsides
Sinus headache or nasal irritation (nasal) · short duration (3-6 h) · mild next-morning hangover/tiredness · lower libido (isolated reports) · paradoxical anxiety or depressive dip in a minority, resolves after stopping
Evidence
Approved drug — approved in Russia (Selank 0.15% nasal, reg. 2009); small human trials (GAD vs medazepam, n=62)
Caveat
No mechanistic red flag (GABA-A modulation, enkephalinase inhibition, IL-6 modulation), but Western-quality human data are thin. A handful of users report a bad reaction after a single dose that took weeks to fade; start low. FDA lists 'insufficient information' rather than a specific harm.
Typical use
250-500 mcg/day nasal or subq, often 5 days on/2 off or 2-4 week cycles; titrate from 100-200 mcg.
Getting it
Pharmacy drug in Russia (0.15% nasal drops); elsewhere research-peptide vials and nasal sprays.
Stacked with
Semax: The classic pairing: Semax in the morning for focus, Selank later for calm; several use both before public speaking. · Benzodiazepines or SSRIs: Many reports come from people on an SSRI or tapering a benzo; a Russian trial used it as add-on to phenazepam, but bad reactions also cluster in people on psychiatric drugs. · GB-115: Run together or rotated for anxiety; users describe Selank as calming the mind and GB-115 the body.
Started selank last month, 0.48mg intranasally once a day and WOW. A social situation that would have me at 7/10 tension is now a 3/10 at most. Physical symptoms - gone.
GlowingSocial · 480 mcg once daily · Nasal · 1 month (later 21 on / 7 off)
Girl same, my entire life has been constant overthinking constant catastrophizing, zero trust for anyone in my life One week intranasal selank, poof. Gone. Without any side effects?
I can say confidently at 300mcg a dose this stuff has been absolutely a life changer. My only complaint is that it doesn't seem to last more than 5 hours...
GlowingSocial · 300 mcg · Injection
lifelong social anxiety, never on SSRIs (thread OP)
Selank is the best thing I have ever taken for GAD. I am on 15mg Escitalopram, while it helps with the pounding heart, it never quieted all the noise (rumination, doom and gloom, etc). Exactly the morning after taking Selank nasal spray, all the noise was gone.
Glowing1 spray per nostril 2x/day, then 1x/day · Nasal · 4 weeks
Two months in and my anxiety is gone. As someone who’s struggled with severe anxiety and depression since I was 12 this feels amazing, and has changed my life
after my first cycle of it, even off of it, my baseline anxiety is noticeably lower and my social anxiety has dramatically decreased. most times i don’t feel as i need it anymore.
GlowingSocial · 400 mcg each morning · repeated 2-3 week cycles
Selank at night calms the nervous system without making you feel sedated🏴☠️ What I have noticed since the split 🏴☠️ I fall asleep faster than I have since starting reta no doubt🏴☠️ Stay asleep through out the night now 🏴☠️
For the first 2 weeks I did not notice much from Selank. I originally got it to balance out Semax and reduce anxiety or jitters, since I had read it was the “perfect combo.” It was not until around week 3 that I really started noticing some changes.
I use semax and selank before any public speaking engagement. What used to be a horrible struggle is now something I can look forward to. Words come easy and anxiety melts away.
I have a long history of generalized anxiety disorder. I added SELANK to my stack. 20 units a day 10mg vial It has helped take away the physical symptoms of anxiety immensely.
Positive500 mcg/day · Injection · 2 weeks
GAD, on low-dose sertraline after stopping fluoxetine
Like I’ll have periods of time where every day my heart is just pounding in anxiety, even if I have no mental anxiety And like 24-48Hrs after doing 600-1200mcg selank intranssally it goes away. Although it could be placebo effect
i've run selank a few times and it's subtle, almost to the point where you question if it's doing anything. 400-500mcg was the sweet spot for me but the effect is more about what doesn't happen, less mental chatter, less of that background tension
In the three years since I left this comment, I have tried several different Selank formulations and some have worked really well for depression and anxiety. It's a temporary fix but it genuinely works, if the product is good.
I’ve been using Selank (and more potent modern versions) for decades to help me get to sleep. As someone with severe ADHD, it’s one of the few things that actually works.
Since I've started taking it (like 1-2 weeks ago) my general anxiety decreased a lot, no adverse effects. I'd say, my behaviour got even more confident, than the subjective feeling.
There is no body feel or mental impairment like with benzos or beta blockers. It is most notable daily in public speaking, where my general anxiety went from like a 6-8/10 to maybe 2/10
PositiveSocial · 250-500 mcg each morning · Injection
I didn’t feel much on selank but i will say i did notice the effects when i least expected it. During high stress situations & times where id feel overwhelmed or frustrated, I wasn’t. I was calm and collected.
After the first dose I finally am free from social anxiety and many of my ND social issues. I easily hold eye contact and can make small talk no problem!
MixedSocial · 0.3 mL Mon/Wed/Fri (pharmacy-dispensed) · Injection · 3 separate weeks
Took the nasal spray right before bed the last week Instead of helping me wind down, I felt slightly mentally alert or lightly activated after a few hours ... Conclusion : Taking Selank in the morning or late afternoon works great for me
I thought its calming but for me its the opposite, just pure stress. Its been nearly 10h and i still feel like this, how long does this last and why is this?
For me, the sensation mildly resembles being on cocaine, and by the evening I got extremely irritable, aggressive, mood swings, dry eyes, dizzy and racing thoughts.
I just took my first dose of Selank last night. Started low at 200mcg. I felt like I was having a panic attack, chest was tightening, mind racing, tossing and turning all night.
From day two I already felt a sober kind of mood fall, becoming a more intense depression as the days passed. I also became withdrawn, socially anxious, frightened and small whilst in public, worthless and hopeless.
I wouldn't recommend Selank daily, at least in my experience. Grew a tolerance very fast and started creating anxiety without it + without increasing dose. Similar to Benzos.
selank is QUICKLY becoming my favorite compound to add on to my usual stack on high-stress days and whenever i need more creativity 500 mcg up the nose and i genuinely feel like i could calmly paint the mona lisa inside of a burning building
500mcg this definitely did something and could now see why it’s regarded as an anxiolytic. It’s similar to the feeling of a benzodiazepine except it’s not sedating and there’s no feeling of impairment.
Solid anxiolytic, calming. Find it helps a lot with racing thoughts and overthinking in social situations. Stacks nicely with Semax for a light but effective daily work / social stack
A week in and I’m sleeping better than I have in years, barely moving at night, waking up rested, completely at peace with my morning coffee. ... Now the sex drive seems to have left again.
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The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.
Seen harm
Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.
Mechanism
A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.
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How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.
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Product
The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.
Evidence
The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.
Access
How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.
Price per month
Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.
Dose users report
The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.
Testing
Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.
Added peptide
Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.