PepRank

AHK-Cu (topical)

46%positive20 reports

Also: copper tripeptide AHK · Ala-His-Lys copper(II) · alanyl-histidyl-lysine copper · copper peptide hair serum

CautionSupplement

GHK-Cu's hair-targeted sibling; scalp serum users report baby hairs, but data stop at a dish.

AHK · Cu(II) complex (3 residues)

AHK Cu(II) complex

#6 of 23 supplements · updated
Access
Grey market
Cost / month
≈ €13–90
researchers' estimate; no listing to price
TopicalFelt in 8–12 weeks

Builds over days or weeks of regular use rather than with each dose.

20 user reports
Glowing 1Positive 8Mixed 7Nothing 3Negative 1
  • r/BodyHackGuide· · 41 upvotesOriginal ↗

    The photos attached show just 11 weeks of usage on my temples, and 4 weeks of usage on my lashes. As shown in the hair photo, which I think speaks for itself, my baby hairs have vastly increased in density and thickness.

    GlowingTopical · hair and lash growth (no hair loss)

    No diagnosed hair loss; 11 weeks on temples and 4 on lashes, no other new products or supplements; serum feels like water, no residue.

  • r/Hairtransplant· · 3 upvotesOriginal ↗

    Just measure out the concentration you want on a scale. I did 1%. Been working well.

    Positive1% in 30 ml hyaluronic acid/B5 · Topical · hairline

    Thread author, DIY 1% serum on the hairline; later said he uses it on and off, not consistently.

  • r/BodyHackGuide· · 7 upvotesOriginal ↗

    I’m using GHK-Cu for my skin (and seeing improvements) and AHK-Cu for my hair; I also use minoxidil. But I haven’t seen great results yet (after 1 month of use).

    Nothing0.05 mg rubbed into scalp · Topical · hair loss

    1 month of reconstituted AHK-Cu rubbed into the scalp alongside minoxidil (and GHK-Cu for skin).

Users report
A young, enthusiastic but small topical community (mostly 2025-2026, DIY serums from raw cosmetic powder or premade GHK/AHK sprays). Under half the first-hand reports are clearly positive: new baby hairs at the hairline and temples, a thicker feel, less shedding, usually after 2-3 months. Almost everyone also runs minoxidil, finasteride/dutasteride, microneedling, red light or injected GHK-Cu, so the peptide's own share is hard to see; several are 'feels thicker, too early to tell'. One user saw a heavy shed on a strong 8% GHK/AHK spray. Since mid-2026 many have switched to injecting it, which is a different, unvetted route (see caveat). Felt nothing: ~15% of reports felt nothing; another ~35% were mixed or unattributable.
Best effects
New baby hairs at hairline/temples after 2-3 months · hair feels thicker · less shedding for some · eyelash/brow and beard fill-in (a few reports)
Downsides
DIY mixes leave hair stiff or scaly, HA bases feel tacky · possible shed on high-strength (8%) sprays · slow; most cannot separate it from minoxidil/finasteride · unstable once dissolved (refrigerate, discard if it turns green/brown)
Watch
No human safety or efficacy data at all for AHK-Cu itself; only in-vitro/ex-vivo work and its near-identical structure to the long-used GHK-Cu · In fibroblasts it raises VEGF (Pyo 2007); harmless at topical cosmetic doses, but the reason injecting it carries the same theoretical growth-factor concern as injectable GHK-Cu · Sold mainly as grey-market raw powder of unverified purity, often mixed unpreserved and applied after microneedling: contamination/infection risk from the practice rather than the molecule
Evidence
Animal only — in-vitro and ex-vivo only (human hair-follicle organ culture, dermal papilla cells); no clinical trial
Caveat
Verdict is for the topical cosmetic route only. Injecting AHK-Cu became popular on Reddit in 2026 with zero human data and painful injections; that route belongs with injectable GHK-Cu (excluded). Even topically, the evidence is a single in-vitro paper, so the 'hair-specific copper peptide' claim is marketing-strength.
Typical use
1-2% (10-20 mg/ml) in a preserved hyaluronic-acid or water base, a few drops to thinning areas once or twice daily; refrigerate.
Getting it
Raw AHK-Cu cosmetic powder from bulk peptide sellers mixed into a hyaluronic or distilled-water base, or premade GHK/AHK scalp sprays (e.g. Neurogan 4%+4%, a few Korean hair tonics). No pharmaceutical-grade source.
Stacked with
Minoxidil: nearly every user stacks it; applied at a different time of day · GHK-Cu (topical or injected): common pairing; makes AHK's own effect impossible to isolate · Microneedling: used weekly to boost penetration; only with a preserved, clean serum

User reports 20

  • r/BodyHackGuide· · 41 upvotesOriginal ↗

    The photos attached show just 11 weeks of usage on my temples, and 4 weeks of usage on my lashes. As shown in the hair photo, which I think speaks for itself, my baby hairs have vastly increased in density and thickness.

    GlowingTopical · hair and lash growth (no hair loss)

    No diagnosed hair loss; 11 weeks on temples and 4 on lashes, no other new products or supplements; serum feels like water, no residue.

  • r/Hairtransplant· · 3 upvotesOriginal ↗

    Just measure out the concentration you want on a scale. I did 1%. Been working well.

    Positive1% in 30 ml hyaluronic acid/B5 · Topical · hairline

    Thread author, DIY 1% serum on the hairline; later said he uses it on and off, not consistently.

  • r/HairlossResearch· · 2 upvotesOriginal ↗

    I’ve tried a Korean hair loss product with AHK-Cu and it worked pretty well for me.

    PositiveTopical · hair loss

    Commercial Korean hair-loss product containing AHK-Cu.

  • r/Hairtransplant· · 1 upvotesOriginal ↗

    ive used both with ask-cu and will not be using the hair serum again. Noticeable difference with the hyaluronic acid that I didn't feel or see with the hair serum.

    PositiveTopical · hair growth

    Tried AHK-Cu in two bases; saw a difference only with the hyaluronic-acid base.

  • r/Biohacking· · 1 upvotesOriginal ↗

    ive got quite a few new baby hairs at my hairline, some of which are now darkening and in the past 2-3 weeks my shedding has begun to reduce noticeably in the shower.

    Positivepremade serum, ~2.5 mg/day · Topical · androgenetic alopecia

    AGA since 2023; ~13 weeks of premade AHK-Cu serum on top of a decade of minoxidil, a year of alfatradiol and 1 mm microneedling.

  • r/Minoxbeards· · 1 upvotesOriginal ↗

    I did the shots for a while got very little from that I switched to ghk / ahk topical mixed with HA and started seeing results within 1-2 weeks

    PositiveTopical · facial hair growth (minoxidil alternative)

    43M avoiding minoxidil; injections did little, switched to topical GHK+AHK in hyaluronic acid.

  • r/Biohacking· · 1 upvotesOriginal ↗

    I mix with distilled water and use it daily, 1x weekly dermaroll on scalp. Moderate regrowth all around. I'm quite happy. I don't use anything else.

    Positive~250 mcg per 30 ml distilled water, daily · Topical · hair thinning

    AHK-Cu in distilled water daily with weekly dermarolling, no other treatment.

  • r/tressless· Original ↗

    Topicals are super safe girly. I’ve been doing 4% GHK/AHK for months with great results

    Positive4% GHK/AHK · Topical · hair loss

    Months of a 4% GHK/AHK topical; no detail on other treatments.

  • r/hairgrowth· Original ↗

    AHK-cu seems to be the only thing I have seen working. I bought some in Aus and it worked for me.

    Positivehair growth

    Comment in a thread on The Ordinary serum; bought AHK-Cu in Australia, route not stated.

  • r/tressless· · 7 upvotesOriginal ↗

    Can’t say it helped at all but it did made my hair look cosmetically thicker and when I started it somewhat made my scalp feel healthier and less dry

    MixedTopical · hair loss

    GHK/AHK serum used irregularly for 6-9 months alongside topical minoxidil.

  • r/Peptidesource· · 5 upvotesOriginal ↗

    I have since obtained topical ahk-cu and Ghk-CU and have been applying it for 2 months. I am also running Ghk-CU subq in intervals. Hairs continue to pop up and my hair is getting thicker.

    MixedTopical · receding hairline

    Topical AHK+GHK for 2 months on top of minoxidil, earlier finasteride and intermittent injected GHK-Cu/KLOW; the user himself cannot credit the topical.

  • r/Biohacking· · 2 upvotesOriginal ↗

    I mixed 1g AHK-Cu and 1g GHK-CU into ordinary serum. I’m probably 45 days in(on 2nd bottle). I haven’t noticed much. Maybe not losing as much.

    Mixed1 g AHK-Cu + 1 g GHK-Cu in a 60 ml serum · Topical · hair loss

    45 days, on top of topical and oral minoxidil, dutasteride and injected KLOW.

  • r/Hairtransplant· · 1 upvotesOriginal ↗

    Too soon to tell on visual additional growth. But my hair does feel thicker.

    MixedTopical · thinning hair

    DIY serum, roughly 3 months in.

  • r/Biohacking· · 1 upvotesOriginal ↗

    Ive been doing topical AHK for about 4 months and am a month in pinning GHK. I also do RLT. Have started seeing progress in the last month or so. Still early but I am pleased with the results so far

    Mixed1-2 g powder in water + The Ordinary hair serum, ~5x/week · Topical · hair loss

    4 months topical AHK with red light; progress appeared in the same month he started injecting GHK-Cu, so not attributable.

  • r/greyhairreversal· · 1 upvotesOriginal ↗

    I've used ghk-cu and ahk-cu topically for a few months at least, but not sure if it has helped as I dye my hair. Definitely a bit thicker though.

    MixedTopical · grey hair / thickness

    Topical GHK+AHK for a few months.

  • r/HairlossResearch· · 1 upvotesOriginal ↗

    Ive only been doing this about 2 months I think so maybe it takes longer but its not the miracle that others have posted here

    MixedTopical · hair loss

    Months of a premade GHK-Cu serum with moderate results, then ~2 months with AHK-Cu powder added to it.

  • r/BodyHackGuide· · 7 upvotesOriginal ↗

    I’m using GHK-Cu for my skin (and seeing improvements) and AHK-Cu for my hair; I also use minoxidil. But I haven’t seen great results yet (after 1 month of use).

    Nothing0.05 mg rubbed into scalp · Topical · hair loss

    1 month of reconstituted AHK-Cu rubbed into the scalp alongside minoxidil (and GHK-Cu for skin).

  • r/tressless· · 2 upvotesOriginal ↗

    I have been doing this for about 4 months with no noticeable improvement. Just added AHKCU about a month ago, but it’s difficult to source

    NothingTopical · hair loss

    4 months of topical copper peptides with no change; AHK-Cu added for the last month.

  • r/Hairtransplant· · 1 upvotesOriginal ↗

    Been using it morning and night along side micro needling (every 2-3days). Still nothing. So far I am only about 3 weeks in so not expecting much

    Nothing2% in The Ordinary HA, twice daily · Topical · hair loss

    3 weeks, morning and night, with microneedling every 2-3 days; early.

  • r/tressless· · 4 upvotesOriginal ↗

    I started noticing very mild shedding about a month into the peptide serum, but it’s ramped up concerningly since then.

    Negative8% spray (4% GHK-Cu + 4% AHK-Cu) · Topical · androgenetic alopecia

    7 weeks of Neurogan 8% GHK/AHK spray added to long-term finasteride 1 mg and topical minoxidil.

Safety

Tier by safety barStrict CautionBalanced CautionEvidence only Clean

Seen harmMechanismData gapSilent harmProduct

Seen harm 0/3
No study and about twenty first-hand reports, the only negative one a shed on a combined GHK/AHK spray. r/tressless: shedding with a GHK/AHK serum ↗
Mechanism 1/3
Raised VEGF and dermal papilla proliferation in follicle cultures; topical cosmetic doses give negligible systemic exposure, so a growth-factor harm is speculative for this route. Pyo et al. 2007: AHK-Cu and human hair follicles ex vivo, the only study (PubMed 17703734) ↗
Data gap 3/3
No human safety or efficacy data at all; the entire evidence base is one 2007 ex-vivo study, and GHK-Cu's cosmetic record bridges only by structural analogy. Pyo et al. 2007: AHK-Cu and human hair follicles ex vivo, the only study (PubMed 17703734) ↗
Silent harm 1/3
Scalp irritation and shedding are noticed within weeks.
Product 2/3
Mostly raw grey-market powder mixed at home, unpreserved and often applied after microneedling; a few premade sprays exist.
Never if
Wilson disease or copper allergy · Pregnancy or breastfeeding (no human reproductive data)

Where to buy 5 in Europe · 6 total

ShopFormPricePer mgTesting
iHerbUSserum · 1800 mg€69€0.039/mgNo public testsout of stock
CertaPeptidesEU · ROpowder · 100 mgcontents not stated€40€0.40/mgThird-party tested
CertaPeptidesEU · ROpowder · 50 mgcontents not stated€24€0.48/mgThird-party tested
Condor ResearchEU · SKpowder · 100 mg€55€0.55/mgNo public tests
Europa-PeptideEU · PLpowder · 50 mg€48€0.96/mgOwn COA
Amazon.frEU · FRserum+GHK-Cu (copper tripeptide-1)+4 other actives€46—No public tests

Studies 2

Sources 3

More in Skin & hair all 17 →

  1. 1EGF serum (sh-oligopeptide-1) CautionSupplement Topical≈ €13–81 / month59%positive24 reportsRecombinant human growth factor in serums; users like the glow, but keep it off broken or microneedled skin.
  2. 2GHK-Cu (topical) GHK (3 residues) CautionSupplement ≈ €9–36 / month59%positive44 reportsDecades-old cosmetic copper peptide; gentle skin firmness/texture and possibly hair benefits.
  3. 3SYN-AKE (dipeptide diaminobutyroyl benzylamide diacetate) CautionSupplement Topical≈ €4–27 / month57%positive18 reportsSynthetic 'snake venom' peptide for expression lines; mostly a K-beauty sheet-mask ingredient, mild at best.
  4. 4Leuphasyl (pentapeptide-18) CautionSupplement Topical≈ €4–27 / month55%positive1 reportsEnkephalin-mimic expression-line peptide, sold as argireline's partner; hard to find alone, barely reviewed.
  5. 5Argireline (acetyl hexapeptide-8) EEMQRR (6 residues) CautionSupplement Topical≈ €4–13 / month48%positive25 reportsSNAP-25-mimic 'topical Botox' for expression lines; real but mild softening for about half of users.
  6. 6Collagen peptides (oral) CleanSupplement ≈ €11–16 / month49%positive47 reportsFood-grade protein; modest, slow, inconsistent benefits for skin, nails and joints.
  7. 7SNAP-8 (acetyl octapeptide-3) EEMQRRAD (8 residues) Caution Topical≈ €9–22 / month45%positive12 reportsArgireline's longer sibling, mostly DIY-mixed from peptide vials; users rarely see more than argireline.
  8. 8Tricomin CautionSupplement Topical≈ €27–63 / month43%positive1 reports1990s ProCyte copper-peptide hair spray, now an AHK-Cu cosmetic; one unpublished small trial, users shrug.
  9. 9Matrixyl (palmitoyl pentapeptide-4) KTTKS (5 residues) CleanSupplement Topical≈ €4–13 / month45%positive21 reportsThe classic 'collagen-signal' cosmetic peptide; slow, soft smoothing, more hydration than lift.
  10. 10Biotinoyl tripeptide-1 (Procapil) & Capixyl hair serums GHK (3 residues) CautionSupplement Topical≈ €10–20 / month42%positive25 reportsCosmetic anti-shedding peptides in cheap leave-on scalp serums; a minority see baby hairs.
  11. 11Nonapeptide-1 (Melanostatine 5) CautionSupplement Topical≈ €4–13 / month45%positive12 reportsAlpha-MSH blocker for dark spots, always sold beside stronger lighteners; its own effect is untested.
  12. 12Hexapeptide-9 (Collaxyl) CautionSupplement Topical≈ €4–27 / month3/10estimateCollagen-sequence 'signal' peptide in firming serums; tested in people only as a modified or enhanced version.
  13. 13Tripeptide-10 citrulline (Decorinyl) CautionSupplement Topical≈ €4–27 / month3/10estimateDecorin-mimic peptide meant to tidy collagen fibres; one tiny randomised trial, no user reports.
  14. 14Melanotan II DHFRWK (6 residues) Excluded Nasal / Injection≈ €27–54 / month51%positive51 reportsNon-selective melanocortin agonist for tanning; works, but has documented serious harms.Documented serious harms (melanoma reports, PRES, priapism) from non-selective melanocortin activation.
  15. 15GHK-Cu (injectable) GHK (3 residues) Excluded Injection≈ €20–40 / month50%positive30 reportsHugely popular for skin tightening and hair; supraphysiologic systemic dosing with no human data.Borderline: theoretical growth-factor/angiogenic signalling at supraphysiological systemic doses with no human injectable safety data. Topical GHK-Cu gives much of the skin benefit without this.
  16. 16PTD-DBM Excluded Topical≈ €36–90 / month42%positive6 reportsWnt-activating hair-regrowth peptide from mouse studies; DIY users report little.It works by switching on Wnt/beta-catenin signalling in skin, and sustained beta-catenin activation causes hair-follicle tumours in mice and pilomatricoma in humans. It has no human safety data, and users pair it with valproic acid, a teratogen.

Sequence beads

Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.

non-polarpolarpositivenegative

Report grades

Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.

GlowingPositiveMixedNothingNegativeBad reaction

% positive

The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.

Researcher estimate

No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.

Safety tier

Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.

Safety bar

The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.

Seen harm

Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.

Mechanism

A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.

Data gap

How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.

Silent harm

Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.

Product

The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.

Evidence

The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.

Access

How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.

Price per month

Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.

Dose users report

The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.

Testing

Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.

Added peptide

Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.