i was on a bit of a stall with Tirzepatide and added this in...first in the morning...for 3 weeks, nothing. I changed it up 2 weeks ago to the evening. losing 1.5lbs/week!
Positive300 mcg, 2 hours after the evening meal · Injection · 5 weeks
In the 8 weeks since starting AOD, I have lost 12" total from chest/waist/navel/upper and lower hip/thigh. In the 8 weeks prior to AOD, I only lost 6" total from those same points.
Positive250 mcg twice daily · Injection · 8 weeks
on tirzepatide 15 mg throughout, 10 lb from goal; tracked tape measurements weekly
I'm honestly not sure if the AOD is working or if I will need to do it for longer amount of time.
Negative0.04 ml daily, fasted · Injection · 1 month
lean woman also running CJC-1295, a GHK/BPC/TB blend and NAD, so the GI effect is not pinned on AOD
Users report
About half of the reports claim fat loss or a broken stall, but almost every success story is confounded by tirzepatide/retatrutide plus a diet. Experienced users repeat that it lost to placebo and was scrapped in 2007 (those trials used oral doses; users inject). The most common practical complaint is vials going cloudy or gelling. Roughly 35-40% notice nothing, and a few say they stalled or regained weight while on it.
Best effects
Fat loss (not supported by RCTs) · joint/cartilage claims (animal only)
Downsides
No measurable effect for most · cloudy/gelling reconstitution · injection sting
Watch
Generic: grey-market purity; FDA noted serious adverse events of unclear causality and immunogenicity concerns for compounded forms
Evidence
Human RCTs — Six double-blind trials, ~900 people: no IGF-1 or glucose effect, placebo-like tolerability, efficacy failed
Typical use
250-500 mcg/day subQ, fasted, before cardio. In practice not worth it.
Getting it
Research-peptide vendors and a few compounders; vials often go cloudy or gel in plain bacteriostatic water.
Stacked with
Tirzepatide or retatrutide: almost every success story; users add AOD to break a GLP-1 stall. · fasted cardio: injected on waking or at night, fasted, on the theory that released fat must be burned. · tesamorelin or CJC-1295/ipamorelin: common GH-axis add-ons that further confound any AOD effect.
i was on a bit of a stall with Tirzepatide and added this in...first in the morning...for 3 weeks, nothing. I changed it up 2 weeks ago to the evening. losing 1.5lbs/week!
Positive300 mcg, 2 hours after the evening meal · Injection · 5 weeks
In the 8 weeks since starting AOD, I have lost 12" total from chest/waist/navel/upper and lower hip/thigh. In the 8 weeks prior to AOD, I only lost 6" total from those same points.
Positive250 mcg twice daily · Injection · 8 weeks
on tirzepatide 15 mg throughout, 10 lb from goal; tracked tape measurements weekly
Agreed that AOD just isn't comparable to GLP meds, but in my experience, it does give a noticeable boost to weight/fat loss in obese subjects. It has broken my subjects stall every time they restarted it.
Positive300 mcg fasted each morning · Injection
obese, on a GLP-1 drug; notes a wave of underdosed or gelling vials
I really like AOD. I use it M-F first thing in the morning. It's really good for people with very little visceral fat. It's not a jackhammer. More of a chisel.
AOD used during a fasted training session does indeed help to burn the midsection. Been using it about 3 weeks and it's done great for me. Been on Reta for 10 weeks
Positivebefore fasted training · Injection · 3 weeks
I use it with hGH to get the lipolysis advantages without taking too high of a hGH dose… to avoid water attention/wrist pain) and it's great but I really needed like 4+ months/I thought it wasn't working
Used with reta in Nov ... nothing , put it in the back of the freezer. Figured id use up remaining viles a little over 2 weeks ago ... like rocket fuel .
For the first month, it seemed to boost my weight loss by 0.2 lbs/week. This was in addition to what I was already losing on tirz. But after that, I didn't notice it making any difference.
NothingInjection · 3 months, then 1 more month after a break
Then I added AOD 9604. I gained back 5 pounds and was stuck there for 2 weeks. I quit the AOD 9604 and immediately lost those 5 pounds and 2 more in less than a week.
NegativeInjection · 2 weeks
on tirzepatide and cagrilintide; weight fell again once AOD was stopped
I want to discuss whether or not these peptides are actually worth the money. Right off the bat, I'm going to tell you that the price of growth hormone from the distributor I've set you guys up with is actually a better price than both of these peptides and works better.
NothingInjection · vendor-adjacent
post steers readers to HGH from a distributor the author has "set you guys up with"
Safety
Tier by safety barStrict CautionBalanced CautionEvidence only Caution
Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.
non-polarpolarpositivenegative
Report grades
Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.
GlowingPositiveMixedNothingNegativeBad reaction
% positive
The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.
Researcher estimate
No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.
Safety tier
Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.
Safety bar
The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.
Seen harm
Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.
Mechanism
A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.
Data gap
How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.
Silent harm
Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.
Product
The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.
Evidence
The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.
Access
How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.
Price per month
Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.
Dose users report
The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.
Testing
Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.
Added peptide
Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.