I’ve now started full-dose VIP and the first day I was on it, I could see clearly for the first time in a decade and my personality felt like it’s been coming back! A couple days later and I have energy!!!
GlowingEnergy · Nasal
CIRS with POTS, EDS, MCAS, CFS; started full dose after clearing MARCoNS under a Shoemaker practitioner
I was told that the biofilm from MARCoNS prevents VIP from being absorbed...and my experience on VIP bore this out (got nothing).
NothingNasal
taken while MARCoNS were still present
Strict case
Significant cardiovascular action (vasodilation/hypotension) and broad immunomodulation; a supervised CIRS therapy, not a general-health peptide.
Users report
In the CIRS/mould community some describe it as life-giving ('could see clearly for the first time in a decade'). Others notice nothing or say it 'helped but wasn't a cure'. Many react badly if not fully detoxed first, and some had to titrate over months while watching for low blood pressure.
Best effects
Energy and cognition in CIRS · lower inflammatory markers (CIRS) · visual contrast / fog lifting (anecdotal)
Potent vasodilator: hypotension and tachycardia · Broad immunomodulatory and secretory effects (VIPoma-like diarrhoea at high exposure)
Evidence
Human RCTs — Aviptadil RCTs in COVID ARDS were negative; CIRS data are uncontrolled case series
Typical use
CIRS protocol: titrated up to ~50 mcg nasal several times daily, only after exposure removal and lab-guided prerequisites. Users report 200–500 mcg/day (median 400 mcg, n=5).
Getting it
US compounding pharmacies make the nasal spray on prescription from CIRS (Shoemaker) practitioners; aviptadil itself is unapproved in the US, though an aviptadil-phentolamine injection is licensed for erectile dysfunction in the UK and Scandinavia. Grey-market vials are mixed into DIY sprays.
Stacked with
Cholestyramine or Welchol (binders): The Shoemaker protocol puts VIP last, after binders, MARCoNS clearance and normal MMP-9; users who start early report the worst reactions. · Vilon: A long-COVID/ME-CFS nasal-spray combo from one widely shared post; its author later said only about a quarter of those who tried it responded. · KPV, BPC-157, LL-37 and thymosin alpha-1: Peptide-clinic gut and immune stacks for SIBO, MCAS and mould illness, in which VIP's own effect cannot be separated.
I’ve now started full-dose VIP and the first day I was on it, I could see clearly for the first time in a decade and my personality felt like it’s been coming back! A couple days later and I have energy!!!
GlowingEnergy · Nasal
CIRS with POTS, EDS, MCAS, CFS; started full dose after clearing MARCoNS under a Shoemaker practitioner
I've been taking it for a month and I'm finally able to start treating SIBO, as well as take things that normally make me constipated, like TUDCA, MegaIGG 2000, and activated charcoal.
I passed vision contrast, off binders, walking 5 miles a day. I had significant atrophy so that will take awhile. Hence, stay on vip. That has been my miracle treatment.
It made a massive difference. Started out as just random moments here and there after dosing of mental clarity, and improved VCS also started getting reduced pain and increase in lung capacity and I can exert my body again even started jogging and going on long walks.
I just have the n of 1 and it was mold related. It completely removed a significant tremor I was experiencing. It was IV and this type of intervention should only be done with an expert
I made nasal sprays and had used them for about three months when I first did a major travel day (12 hours including a long flight) and did not get PEM after. I had PEM for almost three years before this.
PositiveEnergy · Nasal · ~3 months
long COVID/ME-CFS; homemade VIP + Vilon sprays alongside other anti-inflammatory supplements
VIP worked well for me when I was years out from major mold illness. My husband who had lyme/mold never really responded to it (even seemed to make him worse as I recall).
Fatigue, hormonal issues, neuropathy, constant headaches/migraines, and water retention issues like cramping all improved significantly or disappeared completely.
PositiveEnergy · Nasal · 4 months
CIRS last stage; also moved home in the same period
It took me maybe 6 months to work up to a full dose. It was really bad at first, but once I got used to it and slowed it down it helped so much. I had to look out for low blood pressure when I took it, like more light headed.
I did full dose VIP and felt terrible after 10 days. I went back and tried 100 X and 1000 X, but I don’t think I’m over the initial strong dose. I’m ready to give up on VIP because my symptoms were too bad with it.
After about two days, I found that it was super difficult to go to sleep, and also that I was waking up about two hour earlier than usual without being able to go back to bed, even though I was super tired.
I am on 60 days of VIP, (50mcg x 8). Many symptoms I thought were gone have come back strong, including seizures and apnea (not breathing). I am also experiencing extreme hopelessness, like nothing matters and never will again.
Bad reactionMood · 50 mcg x 8/day · Nasal · 60 days
I stopped VIP 3 weeks ago too and I’m still bedridden. I won’t take it ever again, I’ll just clear MARCONS if I can and continue on with my life. It’s not worth it for me
Bad reaction~5 sprays over a week · Nasal
CIRS at ~60% baseline after a year of treatment; MARCoNS not tested before starting and later suspected positive
Each bead is one amino acid in the peptide's chain, coloured by its side chain: grey for non-polar, cyan for polar, blue for positively charged and fuchsia for negatively charged. Length and mix tell related peptides apart at a glance, from a two-residue dipeptide like carnosine to a 43-residue protein like thymosin beta-4. The colours describe chemistry only and predict neither effect nor safety.
non-polarpolarpositivenegative
Report grades
Every first-hand Reddit or X report is graded on its own, from glowing through positive, mixed, nothing and negative to bad reaction, and the bar shows how those grades split. Posts that look vendor-adjacent stay on the peptide's page but are left out of the counts.
GlowingPositiveMixedNothingNegativeBad reaction
% positive
The share of a peptide's graded Reddit and X reports that are glowing or positive, vendor-adjacent posts left out. A peptide with few reports is pulled toward the average of all reports, as if it had eight average ones besides its own, so two glowing posts cannot top the list. Kept peptides rank by the same reports' mean grade, shrunk the same way, and excluded ones follow in that order.
Researcher estimate
No first-hand report of this peptide has been graded yet, so the figure is the researchers' own rating out of 10 from what they read about it. It ranks alongside the computed scores until reports arrive.
Safety tier
Each peptide is tiered clean, caution or excluded from its five risk axes under the chosen safety bar. An excluded peptide has a plausible route to serious harm, so it stays listed with the reason but ranks behind every other entry, however good its reviews.
Safety bar
The safety bar sets how much risk it takes to exclude a peptide. Strict: out on any serious mechanism with little human data, or any documented serious harm. Balanced: out on documented serious harm (unless it is obvious, reversible and from a regulated product), or a serious mechanism whose harm would be silent with no human data at all. Evidence only: out only on documented serious harm in humans that is lasting, delayed or from grey-market product.
Seen harm
Documented serious adverse events in humans, from 0 for none despite real exposure to 3 for deaths or several well-documented serious harms. Serious means a hospital or emergency visit or harm lasting weeks, so a headache or a bad night does not count.
Mechanism
A plausible biological route to serious harm at the doses people use, such as growth-factor signalling, hormone-axis suppression, heart or blood-pressure effects or immune activation. It runs from 0 when none is known to 3 when a dangerous pathway has been shown in living animals.
Data gap
How little human safety data exists for the molecule actually sold, from 0 for an approved drug with large trials and years of use to 3 for no human safety data at all. A modified analogue does not inherit its parent's trials.
Silent harm
Whether the feared harm would show quickly or stay hidden, from 0 when it is obvious and goes on stopping to 3 when it is silent and delayed, like tumour promotion or slow organ damage. User reports cannot reveal a harm that takes years to appear, so a high score here limits what good reviews can tell you.
Product
The risk of what people actually buy, from 0 for a regulated pharmacy or supplement product taken by mouth or on the skin to 3 for a grey-market injectable. In one dataset of 6,441 grey-market samples, 42–71% failed basic quality criteria and 15% carried endotoxin.
Evidence
The strongest kind of study behind the peptide's effects, from an approved drug through human controlled trials and small human studies to animal work or nothing of its own. Animal results often fail to carry over to people.
Access
How people get it: as an approved drug, a compounded prescription, an over-the-counter supplement or from the grey market, where nobody checks the vial. The channel decides both the legal position and the risk of a bad batch.
Price per month
Thirty days of the typical dose, from its low end to its high end, priced at the listing a careful buyer would choose: in stock, from a shop scoring 4 of 5 on trust (third-party tested where no score is set), failing that 3, a pure pack before a blend, a European shop first, then the cheapest per mg. The range is the dose's, not the shops'. A per-dose amount counts once a day unless the dose says otherwise. Prices are in euros at ECB rates of 2026-10-29, before shipping; the shop table keeps each listing's price per mg, per gram for bulk supplements. Where no listing can be priced the researchers' own estimate stands in, and says so.
Dose users report
The middle half of the daily doses stated in at least five first-hand reports, vendor posts left out. Where its middle sits more than twice above or below the declared dose, the month is priced at it as well, since what people take is what they pay for.
Testing
Whether the shop publishes lab results: third-party tested means an independent lab checks each batch, own COA means the shop's own certificate of analysis, and no public tests means neither. A certificate shows purity, not safety.
Added peptide
Some packs sold under one peptide's name hold a second one, such as 5 mg GHK-Cu in a nasal kit, stated only in the description. Sprayed in the nose or injected it reaches the blood like an injection, so it carries the risk of that route and is tiered as the injectable form, whatever its tier on the skin. A pack whose page gives no contents list may hold more than its name.